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Circuit coordination of opposing neuropeptide and neurotransmitter signals - Nature
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Fast-acting neurotransmitters and slow, modulatory neuropeptides are co-released from neurons in the central nervous system, albeit from distinct synaptic vesicles1. The mechanisms of how co-released neurotransmitters and neuropeptides that have opposing actions—for example, stimulatory versus inhibitory—work together to exert control of neural circuit output remain unclear.
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