A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions which stabilizes the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein structures in eukaryotic cells. Xenopus laevis TFIIIA was originally demonstrated to contain zinc and require the metal for function in 1983, the first such reported zinc requirement for a gene regulatory protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins.