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COLIBACTIN

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Colibactin is a genotoxic metabolite produced by Escherichia coli and other Enterobacteriaceae believed to cause mutations leading to colorectal cancer and the progression of colorectal cancer. Colibactin is a polyketide peptide that can form interstrand crosslinks in DNA. Colibactin is only produced by bacterial strains containing a polyketide synthase genomic island or clb biosynthetic gene cluster. About 20% of humans are colonized with E. coli that harbor the pks island.
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