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Transient loss of Polycomb components induces an epigenetic cancer fate - Nature

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Transient loss of Polycomb components induces an epigenetic cancer fate - Nature

Although cancer initiation and progression are generally associated with the accumulation of somatic mutations1,2, substantial epigenomic alterations underlie many aspects of tumorigenesis and cancer susceptibility3–6, suggesting that genetic mechanisms might not be the only drivers of malignant transformation7. However, whether purely non-genetic mechanisms are sufficient to initiate tumorigenesis irrespective of mutations has been unknown.

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Transient loss of Polycomb components induces an epigenetic cancer fate - Nature

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Transient loss of Polycomb components induces an epigenetic cancer fate - Nature

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