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Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects - Nature Methods

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Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects - Nature Methods

Addressing interfacial effects during specimen preparation in cryogenic electron microscopy remains challenging. Here we introduce ESI-cryoPrep, a specimen preparation method based on electrospray ionization in native mass spectrometry, designed to alleviate issues associated with protein denaturation or preferred orientation induced by macromolecule adsorption at interfaces.

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Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects - Nature Methods

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Electrospray-assisted cryo-EM sample preparation to mitigate interfacial effects - Nature Methods

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