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De novo design of pH-responsive self-assembling helical protein filaments - Nature Nanotechnology

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De novo design of pH-responsive self-assembling helical protein filaments - Nature Nanotechnology

Biological evolution has led to precise and dynamic nanostructures that reconfigure in response to pH and other environmental conditions. However, designing micrometre-scale protein nanostructures that are environmentally responsive remains a challenge. Here we describe the de novo design of pH-responsive protein filaments built from subunits containing six or nine buried histidine residues that assemble into micrometre-scale, well-ordered fibres at neutral pH.

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De novo design of pH-responsive self-assembling helical protein filaments - Nature Nanotechnology

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De novo design of pH-responsive self-assembling helical protein filaments - Nature Nanotechnology

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