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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics - Nature Biomedical Engineering

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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics - Nature Biomedical Engineering

Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of inactivated bacteria is poor, and attenuated live bacteria pose substantial safety risks. Here we show that intratumourally injected paraformaldehyde-fixed bacteria coated with manganese dioxide potently activate innate immune activity, modulate the immunosuppressive tumour microenvironment and trigger tumour-specific immune responses and abscopal antitumour responses.

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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics - Nature Biomedical Engineering

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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics - Nature Biomedical Engineering

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