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Severely polarized extracellular acidity around tumour cells - Nature Biomedical Engineering

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Severely polarized extracellular acidity around tumour cells - Nature Biomedical Engineering

Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer cell metabolism and poor vascular perfusion cause the tumour microenvironment to become acidic. Here by leveraging fluorescent pH nanoprobes with a transistor-like activation profile at a pH of 5.3, we show that, in cancer cells, hydronium ions are excreted into a small extracellular region.

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Severely polarized extracellular acidity around tumour cells - Nature Biomedical Engineering

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Severely polarized extracellular acidity around tumour cells - Nature Biomedical Engineering

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