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The PD-1–PD-L1 pathway maintains an immunosuppressive environment essential for neonatal heart regeneration - Nature Cardiovascular Research
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The adult mouse heart responds to injury by scarring with consequent loss of contractile function, whereas the neonatal heart possesses the ability to regenerate. Activation of the immune system is among the first events upon tissue injury. It has been shown that immune response kinetics differ between regeneration and pathological remodeling, yet the underlying mechanisms of the distinct immune reactions during tissue healing remain unclear.
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