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In situ analysis of osmolyte mechanisms of proteome thermal stabilization - Nature Chemical Biology

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In situ analysis of osmolyte mechanisms of proteome thermal stabilization - Nature Chemical Biology

Organisms use organic molecules called osmolytes to adapt to environmental conditions. In vitro studies indicate that osmolytes thermally stabilize proteins, but mechanisms are controversial, and systematic studies within the cellular milieu are lacking. We analyzed Escherichia coli and human protein thermal stabilization by osmolytes in situ and across the proteome.

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environment ecology nature earth mechanisms proteome osmolyte thermal analysis

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In situ analysis of osmolyte mechanisms of proteome thermal stabilization - Nature Chemical Biology

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In situ analysis of osmolyte mechanisms of proteome thermal stabilization - Nature Chemical Biology

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