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Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing - Nature Communications

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Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing - Nature Communications

RNA begins to fold as it is transcribed by an RNA polymerase. Consequently, RNA folding is constrained by the direction and rate of transcription. Understanding how RNA folds into secondary and tertiary structures therefore requires methods for determining the structure of cotranscriptional folding intermediates. Cotranscriptional RNA chemical probing methods accomplish this by systematically probing the structure of nascent RNA that is displayed from an RNA polymerase.

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Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing - Nature Communications

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Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing - Nature Communications

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