Article
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors - Cellular & Molecular Immunology
Rating:
0.0
Views:
36
Likes:
1
Library:
1
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a transcriptomic imprint of CD4+ T-cell help, specifically in T-cell-infiltrated human cancers, and these cells were associated with a good prognosis and response to PD-1-targeting immunotherapy. Here, we delineate the mechanism of cDC1 licensing by CD4+ T cells in humans.
Rating:
0.0
Views:
36
Likes:
1
Library:
1
Rate This Post
Rate The Educational Value
Rate The Ease of Understanding and Presentation
Interesting or Boring? Rate the Entertainment Value