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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors - Cellular & Molecular Immunology

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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors - Cellular & Molecular Immunology

CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We recently identified cDC1s with a transcriptomic imprint of CD4+ T-cell help, specifically in T-cell-infiltrated human cancers, and these cells were associated with a good prognosis and response to PD-1-targeting immunotherapy. Here, we delineate the mechanism of cDC1 licensing by CD4+ T cells in humans.

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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors - Cellular & Molecular Immunology

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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors - Cellular & Molecular Immunology

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for Humanity's Progress