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Metabolic engineering for optimized CAR-T cell therapy - Nature Metabolism

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Metabolic engineering for optimized CAR-T cell therapy - Nature Metabolism

The broad effectiveness of T cell-based therapy for treating solid tumour cancers remains limited. This is partly due to the growing appreciation that immune cells must inhabit and traverse a metabolically demanding tumour environment. Accordingly, recent efforts have centred on using genome-editing technologies to augment T cell-mediated cytotoxicity by manipulating specific metabolic genes.

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Metabolic engineering for optimized CAR-T cell therapy - Nature Metabolism

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Metabolic engineering for optimized CAR-T cell therapy - Nature Metabolism

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