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Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH - Nature Communications

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Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH - Nature Communications

Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress, where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome. Mycobacterium tuberculosis encounters hypoxia (low oxygen) as a major stress in the host macrophages, and upregulates the expression of RafH protein, which is crucial for its survival.

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Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH - Nature Communications

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Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH - Nature Communications

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