Article
Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis - Nature Communications
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Macrophages sense changes in the extracellular matrix environment through the integrins and play a central role in regulation of the reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects the infarcted heart from adverse remodeling and that the protective actions are associated with acquisition of an angiogenic macrophage phenotype.
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