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Bone marrow plasma cells require P2RX4 to sense extracellular ATP - Nature

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Bone marrow plasma cells require P2RX4 to sense extracellular ATP - Nature

Plasma cells produce large quantities of antibodies and so play essential roles in immune protection1. Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow osteoblasts through the gap-junction protein pannexin 3 (PANX3).

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Bone marrow plasma cells require P2RX4 to sense extracellular ATP - Nature

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Bone marrow plasma cells require P2RX4 to sense extracellular ATP - Nature

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