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Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics - npj Precision Oncology
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The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-used gene expression-based classification and has contributed to a better understanding of disease heterogeneity and prognosis. Nevertheless, CMS intratumoral heterogeneity restricts its clinical application, stressing the necessity of further characterizing the composition and architecture of CRC.
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