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3 months ago

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Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization - Cell Death & Differentiation

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Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization - Cell Death & Differentiation

The epigenome coordinates spatial-temporal specific gene expression during development and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval of the epigenetic landscape is a key event in the onset of many pathologies including tumours, where epigenetic changes cooperate with genetic aberrations to establish the neoplastic phenotype and to drive cell plasticity during its evolution.

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Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization - Cell Death & Differentiation

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