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Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity - Nature Communications

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Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity - Nature Communications

Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mechanistic underpinning and functional significance of the NK cell compartment remains incompletely understood. Here, we use photo-labeling, combined with longitudinal transcriptomic and cellular analyses, to interrogate the fate of intratumoral NK cells.

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Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity - Nature Communications

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Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity - Nature Communications

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