@curator

3 months ago

Article

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution - Nature Biotechnology

Rating: 0.0

Likes: 1

Library: 1

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution - Nature Biotechnology

The utility of genetically encoded biosensors for sensing the activity of signaling proteins has been hampered by a lack of strategies for matching sensor sensitivity to the physiological concentration range of the target. Here we used computational protein design to generate intracellular sensors of Ras activity (LOCKR-based Sensor for Ras activity (Ras-LOCKR-S)) and proximity labelers of the Ras signaling environment (LOCKR-based, Ras activity-dependent Proximity Labeler (Ras-LOCKR-PL)).

Rating: 0.0

Likes: 1

Library: 1

Rate This Post

Rate The Educational Value

Rate The Ease of Understanding and Presentation

Interesting or Boring? Rate the Entertainment Value

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution - Nature Biotechnology

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge
for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge
for Humanity's Progress

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution - Nature Biotechnology

Rate This Post

Related Topics

Comments

Media:

My Account:

Boostlane:

Select a Category

Topics Trending Today

Recommended Media

Boostlane Reward System

Unlocking the Power of Knowledge for Humanity's Progress

Quick Links

Select a Locale

Unlocking the Power of Knowledge for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress

Unlocking the Power of Knowledge
for Humanity's Progress