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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion - Nature Immunology

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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion - Nature Immunology

Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how tumor cells adapt to this acidic stress during tumor progression. Here we show that carnosine, a mobile buffering metabolite that accumulates under hypoxia in tumor cells, regulates intracellular pH homeostasis and drives lysosome-dependent tumor immune evasion.

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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion - Nature Immunology

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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion - Nature Immunology

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