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Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing - Nature Biotechnology

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Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing - Nature Biotechnology

Spatial transcriptomics technologies with high resolution often lack high sensitivity in mRNA detection. Here we report a dendrimeric DNA coordinate barcoding design for spatial RNA sequencing (Decoder-seq), which offers both high sensitivity and high resolution.

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Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing - Nature Biotechnology

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Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing - Nature Biotechnology

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