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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth - Oncogene

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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth - Oncogene

Transient early endosome (EE)-mitochondria interactions can mediate mitochondrial iron translocation, but the associated mechanisms are still elusive. We showed that Divalent Metal Transporter 1 (DMT1) sustains mitochondrial iron translocation via EE-mitochondria interactions in triple-negative MDA-MB-231, but not in luminal A T47D breast cancer cells. DMT1 silencing increases labile iron pool (LIP) levels and activates PINK1/Parkin-dependent mitophagy in MDA-MB-231 cells.

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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth - Oncogene

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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth - Oncogene

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