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Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation - Nature Immunology

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Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation - Nature Immunology

The nature of activation signals is essential in determining T cell subset differentiation; however, the features that determine T cell subset preference acquired during intrathymic development remain elusive. Here we show that naive CD4+ T cells generated in the mouse thymic microenvironment lacking Scd1, encoding the enzyme catalyzing oleic acid (OA) production, exhibit enhanced regulatory T (Treg) cell differentiation and attenuated development of experimental autoimmune encephalomyelitis.

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Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation - Nature Immunology

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Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation - Nature Immunology

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