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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes - Nature Immunology

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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes - Nature Immunology

Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require strict control of effector functions. Here we showed that Aiolos, an Ikaros zinc-finger family member encoded by Ikzf3, acted as a regulator of IEL activation. Ikzf3−/− CD8αα+ IELs had elevated expression of NK receptors, cytotoxic enzymes, cytokines and chemokines.

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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes - Nature Immunology

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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes - Nature Immunology

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