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Intermediate conformations of CD4-bound HIV-1 Env heterotrimers - Nature

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Intermediate conformations of CD4-bound HIV-1 Env heterotrimers - Nature

HIV-1 envelope (Env) exhibits distinct conformational changes in response to host receptor (CD4) engagement. Env, a trimer of gp120 and gp41 heterodimers, has been structurally characterized in a closed, prefusion conformation with closely associated gp120s and coreceptor binding sites on gp120 V3 hidden by V1V2 loops1–4 and in fully saturated CD4-bound

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Intermediate conformations of CD4-bound HIV-1 Env heterotrimers - Nature

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Intermediate conformations of CD4-bound HIV-1 Env heterotrimers - Nature

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