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Lysosome regulation of microglia in Alzheimer's disease via TFEB–vacuolar ATPase - Nature Neuroscience

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Lysosome regulation of microglia in Alzheimer's disease via TFEB–vacuolar ATPase - Nature Neuroscience

We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology and defective microglia activation. Our findings demonstrate an essential role of the lysosome in regulating microglia activity in tauopathy and Alzheimer's disease.

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Lysosome regulation of microglia in Alzheimer's disease via TFEB–vacuolar ATPase - Nature Neuroscience

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Lysosome regulation of microglia in Alzheimer's disease via TFEB–vacuolar ATPase - Nature Neuroscience

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