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Biomolecular condensates create phospholipid-enriched microenvironments - Nature Chemical Biology

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Biomolecular condensates create phospholipid-enriched microenvironments - Nature Chemical Biology

Proteins and RNA can phase separate from the aqueous cellular environment to form subcellular compartments called condensates. This process results in a protein–RNA mixture that is chemically different from the surrounding aqueous phase. Here, we use mass spectrometry to characterize the metabolomes of condensates. To test this, we prepared mixtures of phase-separated proteins and extracts of cellular metabolites and identified metabolites enriched in the condensate phase.

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Biomolecular condensates create phospholipid-enriched microenvironments - Nature Chemical Biology

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Biomolecular condensates create phospholipid-enriched microenvironments - Nature Chemical Biology

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