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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis - Nature Cell Biology

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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis - Nature Cell Biology

Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior work has shown that brain cancers and metastases are densely infiltrated with anti-inflammatory, protumourigenic tumour-associated macrophages, but the role of brain-resident microglia remains controversial because they are challenging to discriminate from other tumour-associated macrophages. Using single-cell RNA sequencing, genetic and humanized mouse models, we specifically identify microglia and

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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis - Nature Cell Biology

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Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis - Nature Cell Biology

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