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Structure of the transcribing RNA polymerase II–Elongin complex - Nature Structural & Molecular Biology

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Structure of the transcribing RNA polymerase II–Elongin complex - Nature Structural & Molecular Biology

Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM structures of human Elongin bound to transcribing Pol II. The structures show that Elongin subunit ELOA binds the RPB2 side of Pol II and anchors the ELOB–ELOC subunit heterodimer.

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Structure of the transcribing RNA polymerase II–Elongin complex - Nature Structural & Molecular Biology

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Structure of the transcribing RNA polymerase II–Elongin complex - Nature Structural & Molecular Biology

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