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Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies - Nature Reviews Drug Discovery

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Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies - Nature Reviews Drug Discovery

Chimeric antigen receptor (CAR)-T cells have recently emerged as a powerful therapeutic approach for the treatment of patients with chemotherapy-refractory or relapsed blood cancers, including acute lymphoblastic leukaemia, diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma and multiple myeloma. Nevertheless, resistance to CAR-T cell therapies occurs in most patients.

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Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies - Nature Reviews Drug Discovery

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Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies - Nature Reviews Drug Discovery

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