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IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer - Nature

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IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer - Nature

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to therapies1. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour microenvironment, leading to dysregulated repair and cytotoxic responses. Tumour-associated macrophages (TAMs) have key roles in PDAC2, but their diversity has prevented therapeutic exploitation. Here we combined single-cell and spatial genomics with functional experiments to unravel macrophage functions in pancreatic cancer.

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IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer - Nature

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IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer - Nature

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