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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy - Nature Metabolism

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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy - Nature Metabolism

Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. Senescent cells display a PDK4-dependent increase in aerobic glycolysis and enhanced lactate production but maintain mitochondrial respiration and redox activity, thus adopting a special form of metabolic reprogramming.

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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy - Nature Metabolism

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PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy - Nature Metabolism

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