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A programmable protease-based protein secretion platform for therapeutic applications - Nature Chemical Biology

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A programmable protease-based protein secretion platform for therapeutic applications - Nature Chemical Biology

Cell-based therapies represent potent enabling technologies in biomedical science. However, current genetic control systems for engineered-cell therapies are predominantly based on the transcription or translation of therapeutic outputs. Here we report a protease-based rapid protein secretion system (PASS) that regulates the secretion of pretranslated proteins retained in the endoplasmic reticulum (ER) owing to an ER-retrieval signal.

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A programmable protease-based protein secretion platform for therapeutic applications - Nature Chemical Biology

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A programmable protease-based protein secretion platform for therapeutic applications - Nature Chemical Biology

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