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The glucose transporter 2 regulates CD8+ T cell function via environment sensing - Nature Metabolism

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The glucose transporter 2 regulates CD8+ T cell function via environment sensing - Nature Metabolism

T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the glycolytic pathway are major checkpoints for this event. Here we show that the low-affinity, concentration-dependent glucose transporter 2 (Glut2) regulates the development of CD8+ T cell effector responses in mice by promoting glucose uptake, glycolysis and glucose storage.

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The glucose transporter 2 regulates CD8+ T cell function via environment sensing - Nature Metabolism

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The glucose transporter 2 regulates CD8+ T cell function via environment sensing - Nature Metabolism

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