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Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion - Nature Methods

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Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion - Nature Methods

We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable optogenetic modulation of peripheral nerves in naturally behaving animals during persistent locomotion. The formation of polymeric nanocrystalline domains within the hydrogels yields fibers with low optical losses of 1.07 dB cm−1, Young's modulus of 1.6 MPa, stretchability of 200% and fatigue strength of 1.4 MPa against 30,000 stretch cycles.

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Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion - Nature Methods

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Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion - Nature Methods

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