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Inactivation of the Kv2.1 channel through electromechanical coupling - Nature

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Inactivation of the Kv2.1 channel through electromechanical coupling - Nature

The Kv2.1 voltage-activated potassium (Kv) channel is a prominent delayed-rectifier Kv channel in the mammalian central nervous system, where its mechanisms of activation and inactivation are critical for regulating intrinsic neuronal excitability1,2. Here we present structures of the Kv2.1 channel in a lipid environment using cryo-electron microscopy to provide a framework for exploring its functional mechanisms and how mutations causing epileptic encephalopathies3–7 alter channel activity.

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Inactivation of the Kv2.1 channel through electromechanical coupling - Nature

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Inactivation of the Kv2.1 channel through electromechanical coupling - Nature

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