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Thiol-catalyzed formation of NO-ferroheme regulates intravascular NO signaling - Nature Chemical Biology
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Nitric oxide (NO) is an endogenously produced signaling molecule that regulates blood flow and platelet activation. However, intracellular and intravascular diffusion of NO are limited by scavenging reactions with several hemoproteins, raising questions as to how free NO can signal in hemoprotein-rich environments. We explore the hypothesis that NO can be stabilized as a labile ferrous heme–nitrosyl complex (Fe2+-NO, NO-ferroheme).
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