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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging - Nature Methods

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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging - Nature Methods

Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that captures heterogeneous spatial protein expression patterns at subcellular resolution. Here we report the extension of IMC to low-abundance markers through incorporation of the DNA-based signal amplification by exchange reaction, immuno-SABER.

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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging - Nature Methods

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DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging - Nature Methods

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