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Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria - Nature Chemical Biology

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Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria - Nature Chemical Biology

Hydroxytryptophan serves as a chemical precursor to a variety of bioactive specialized metabolites, including the human neurotransmitter serotonin and the hormone melatonin. Although the human and animal routes to hydroxytryptophan have been known for decades, how bacteria catalyze tryptophan indole hydroxylation remains a mystery. Here we report a class of tryptophan hydroxylases that are involved in various bacterial metabolic pathways.

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Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria - Nature Chemical Biology

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Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria - Nature Chemical Biology

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