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Direct observation of the conformational states of PIEZO1 - Nature

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Direct observation of the conformational states of PIEZO1 - Nature

PIEZOs are mechanosensitive ion channels that convert force into chemoelectric signals1,2 and have essential roles in diverse physiological settings3. In vitro studies have proposed that PIEZO channels transduce mechanical force through the deformation of extensive blades of transmembrane domains emanating from a central ion-conducting pore4–8. However, little is known about how these channels interact with their native environment and which molecular movements underlie activation.

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Direct observation of the conformational states of PIEZO1 - Nature

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