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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature

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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature

Dendritic cells (DCs) have a role in the development and activation of self-reactive pathogenic T cells1,2. Genetic variants that are associated with the function of DCs have been linked to autoimmune disorders3,4, and DCs are therefore attractive therapeutic targets for such diseases. However, developing DC-targeted therapies for autoimmunity requires identification of the mechanisms that regulate DC function.

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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature

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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells - Nature

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