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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division - Nature Immunology

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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division - Nature Immunology

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T cell antigen receptor (TCR) stimulation over days to weeks. However, we know little about the interplay between CD8+ T cell function, cell division and epigenetic remodeling within hours of activation.

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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division - Nature Immunology

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Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division - Nature Immunology

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