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Structural insight into selectivity of amylin and calcitonin receptor agonists - Nature Chemical Biology

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Structural insight into selectivity of amylin and calcitonin receptor agonists - Nature Chemical Biology

Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins, are promising obesity targets. A hallmark of AMYR activation by Amy is the formation of a 'bypass' secondary structural motif (residues S19–P25).

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Structural insight into selectivity of amylin and calcitonin receptor agonists - Nature Chemical Biology

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Structural insight into selectivity of amylin and calcitonin receptor agonists - Nature Chemical Biology

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