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Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition - Nature Metabolism

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Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition - Nature Metabolism

Having direct access to brain vasculature, astrocytes can take up available blood nutrients and metabolize them to fulfil their own energy needs and deliver metabolic intermediates to local synapses1,2. These glial cells should be, therefore, metabolically adaptable to swap different substrates. However, in vitro and in vivo studies consistently show that astrocytes are primarily glycolytic3–7, suggesting glucose is their main metabolic precursor.

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Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition - Nature Metabolism

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Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition - Nature Metabolism

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