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Chiral macrocycle formation within chiral capsules - Nature Synthesis
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Chiral macrocycles are of interest for various applications, including drug discovery, but are challenging to synthesize. Now, a method for enantiocontrolled macrocyclization is demonstrated, involving the confinement of a linear substrate within a self-assembled chiral capsule. This method shows good substrate scope and affords chiral macrocycles with high enantioselectivities and conversions.
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