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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia - Nature Genetics

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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia - Nature Genetics

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly understood. Through deep molecular profiling, we uncovered three transcriptomic subtypes of BCR-ABL1 lymphoblastic leukemia, each representing a maturation arrest at a stage of B-cell progenitor differentiation. An earlier arrest was associated with lineage promiscuity, treatment refractoriness and poor patient outcomes.

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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia - Nature Genetics

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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia - Nature Genetics

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