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11 months ago

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Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin - Nature

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Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin - Nature

Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into immune cells that contribute to disease pathology in peripheral tissues1–4. Outside the marrow, these clones are potentially exposed to a variety of tissue-specific mutational processes, although the consequences of this are unclear.

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Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin - Nature

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Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin - Nature

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