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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization - Nature Structural & Molecular Biology
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Subnuclear compartmentalization has been proposed to play an important role in gene regulation by segregating active and inactive parts of the genome in distinct physical and biochemical environments. During X chromosome inactivation (XCI), the noncoding Xist RNA coats the X chromosome, triggers gene silencing and forms a dense body of heterochromatin from which the transcription machinery appears to be excluded.
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